Publisher's Synopsis
he Second Edition of this comprehensive reference on the retinoids reflects the important advances that have occurred since the publication of the First Edition in 1984. The contributors review current knowledge of new ligands, receptors, mechanisms of cellular action, and molecular mechanisms of control of gene expression by retinoids, and explore the impact of such discoveries on basic science and on clinical applications of retinoids. Coverage includes advances in organic synthesis and analytical chemistry of retinoids and new findings on the role of vitamin A in nutrition, the metabolism of retinol and retinoic acid, the proteins that bind retinoids, the nuclear receptors for retinoic acid, the cell biology of retinoids, and the role of retinoids in vision, embryonic development, and the immune system. A new chapter on toxicology examines the interaction of retinoids with nuclear receptor systems. The book also describes new applications of retinoids in experimental and clinical oncology and in dermatology
